The results are presented in the table below. Vaccine-associated anaphylaxis was rare, approximately one case per million injections, for most known vaccines.Įarlier this month, the CDC's Advisory Committee on Immunization Practices (ACIP) published a report estimating the efficacy of the three US-authorized vaccines compared to the most commonly reported adverse events following immunization, Guillain-Barré syndrome, thrombosis with thrombocytopenia syndrome, and myocarditis. Vaccine-associated anaphylaxis was rare, approximately one case per million injections, for most known vaccines. Severe adverse events (SAEs) were rare, and only were reported in some volunteers as hypersensitivity, facioplegia, urticaria and anaphylactic shock. The researchers pooled 73,633 individuals from 14 randomized controlled trials and compared the risk of adverse events following immunization (AEFI) with 10 different shots. A systematic review and meta-analysis published in early July offered a helpful summary of what we know thus far. That's a single epidemiological study involving one vaccine, though its results match those of clinical trials for all the COVID-19 shots. Our data suggest that the BNT162b2 mRNA COVID-19 vaccine is safe its individual and societal benefits outweigh the low percentage of serious neurologic AEFI. 17 patients required hospitalization fortunately, 16 had been discharged by the end of the study and none had died. “While vaccines may increase the frequency of febrile seizures in children,” they wrote, “in most cases, the coexistence of structural or genetic causes explains epileptic seizure.” Eight of the patients who experienced seizures had preexisting epilepsy or had missed doses of their medication.ĥ,825 (99.6%) of those who experienced any AEFI had a positive history of allergy. Headache was the most common non-serious side effect and seizure the most frequent out of 33 severe reactions, though the researchers suggested that these were probably unrelated to vaccination. Thirty-three serious events were reported 17 (51.5%) were neurologic (observed frequency, 2.4/100,000 doses). Published just this month in Clinical Immunology, the investigation found thatĦ,536 AEFI were reported, of whom 65.1% had at least one neurologic AEFI ( non-serious 99.6%). The study is helpful because it surveyed a large population that was underrepresented in clinical trials conducted in other countries. ![]() Investigating reports to Mexico's Epidemiological Surveillance System, roughly the equivalent of America's VAERS database, a team of researchers examined 704,003 first-dose recipients of the Pfizer-BioNTech vaccine. What do we know about these real-world cases? With the FDA just granting full approval to Pfizer-BioNTech's shot, we have even more safety data. But reports of adverse events inevitably proliferate as vaccine uptake increases. The above review confirms that we started with thoroughly studied vaccines in December 2020. Serious adverse events were reported in four trials: COVID-19 Vaccine AstraZeneca (AZD1222)-168 SAE with only three related to the vaccine - four with none related to the testing vaccine five with Comirnaty (BNT162b1) and one with Covaxin (BBV152) vaccine. Common adverse events were pain at the site of injection, fever, myalgia, fatigue, and headache. In this review, we found the adverse reactions reported in the 11 trials were mild to moderate with few severe reactions which were unrelated to the test vaccine. ![]() The skeptics will continue to cite unverified VAERS data, then quietly discard them once they're investigated and found to be less damning than originally thought.įirst, what do we know from the clinical trials performed before the vaccines were authorized? The FDA evaluated all the safety data reported in the trials, but in March, a team of researchers collected all the adverse events reported during these studies into a handy summary. Read part one: Killer COVID Vaccines? What VAERS Really Tells Us About Coronavirus Shots And Blood ClotsĪs I noted in the first installment, studies of adverse events lag behind the reported adverse events. The skeptical take now seems to be that mass vaccination is injuring and killing untold numbers of people as well as driving the evolution of SARS-COV-2 variants, necessitating dangerous booster shots. That last argument has been addressed elsewhere, so we'll continue our analysis of adverse events from part one. Predictably, these self-reported incidents have provided ample fodder to activist groups and skeptics working to scare people away from effective and very safe immunizations for COVID-19. Many cases of anaphylaxis, myocarditis, Guillain-Barre syndrome, blood-clotting disorders and even Bell's palsy have been reported to the federal Vaccine Adverse Event Reporting System (VAERS) since the first shot was approved last December. COVID-19 vaccination has been linked to a collection of severe side effects.
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